Abstract: Investigating the migration and accumulation of heavy metals in the soil-crop-human system is of great significance for assessing the degree of regional heavy metal accumulate, potential ecological risks, and human health impacts. Based on data from 1∶50,000 eco-geochemical surveys, this study examined the heavy metal contents in the soil-crop-human system and associated health risks in the Shuangyang River basin. The results indicate the enrichment of some heavy metals in soil samples, although their contents fell below the risk screening levels of soil contamination. Heavy metal contents in crop seeds all complied with national food safety standards. Heavy metal contents in women's hair were generally higher than those in men's hair. In some samples, the cadmium (Cd) or mercury (Hg) content exceeded the reference range, showing relatively rich characteristics. In terms of age, the highest heavy metal contents were observed in people aged 41~50, while those of other age groups exhibited decreased heavy metal contents to varying degrees. Crops showed bio-concentration factors (BCF) of soil heavy metals far less than 1, while human hair exhibited BCFs of crop-hosted heavy metals exceeding 1, suggesting that human hair can significantly concentrate and amplify heavy metals. These results indicate a V-shaped pattern of heavy metal migration and accumulation in the soil-crop-human system. The enrichment capacity and contamination degree of individual heavy metals decreased in the order of As, Ni, Cu, Cr, Cd, Pb, Zn, and Hg, with Cd and Hg identified as the primary elements posing potential ecological hazards. The exposure levels and risk indices of non-carcinogenic and carcinogenic pathways decreased in the order of ADD_imouth (average daily dose via oral intake), ADD_idermal (average daily dose via dermal contact), and ADD_ibreathe (average daily dose via inhalation). This result reveals that oral intake represents the primary pathway of health risks associated with heavy metals in the soil-crop-human system in the study area. Therefore, emphasis should be placed on dietary exposure risks in the health risk management of heavy metals. The health risk indices of various heavy metals decreased in the order of As, Cr, Pb, Ni, Cu, Zn, Cd, and Hg. Additionally, children exhibited higher average daily exposure and non-carcinogenic risk indices than adults. While posing insignificant non-carcinogenic risks to adults, heavy metals carried a certain level of non-carcinogenic risks to children presumably due to their physiological characteristics, exposure duration, and dietary intake. This issue warrants attention from local agencies. The results of this study provide a scientific basis for local government departments to accurately assess and warn of human health risks and to develop scientifically robust standards of food safety and environmental protection.