Abstract: The Shamada area in Xizang, located in the eastern segment of the Tethyan-Himalayan tectonic domain, is part of the Kangma-Longzi stratigraphic subregion, representing the most distinctive and significant gold (antimony) metallogenic belt on the Qinghai-Tibet Plateau. In recent years, multiple antimony, gold, and rare metal deposits (ore occurrences) have been discovered in the periphery of the Kangma dome, suggesting superior regional metallogenic conditions and promising prospecting potential. To provide further guidance for the exploration of antimony (Sb), gold (Au), and rare metals in the study area, this study conducted a 1∶50,000 stream sediment survey. Through sample collection and comprehensive test data processing, this study plotted single-element anomaly maps of 17 elements (including Sb and Au) and integrated anomaly maps. In combination with the regional geological setting, eight composite anomalies were delineated in total. The analytical results of geochemical characteristics such as element associations, enrichment coefficients, and coefficients of variation, together with regional geological setting and metallogenic conditions, reveal that primary ore-forming elements in the Shamada area include Sb, Au, arsenic (As), and tungsten (W). Furthermore, the ore-hosted horizons are dominated by the contact interface between the Baidingpu (P₃b) and the Lvcun (T_1-2lc) formations, and important ore-controlling structures in the study area include detachment faults and NW-trending structures. The verification of the HS-2 composite anomaly reveals multiple clues about mineralization. Overall, this study provides a critical basis and technical approach for subsequent mineral exploration deployment and ore prospecting around the Kangma dome.