Abstract: This study investigated data from a 1:50,000 stream sediment survey in the Juxian-Wulian area, Shandong Province using factor analysis. By extracting eight representative factors, this study identified element assemblage types. Then, this study performed geochemical zoning based on the factor scores and discussed the relationships between various sub-zones and their geological background. Based on the geochemical zoning results, as well as geological conditions for mineralization, this study determined favorable geological bodies and prospecting targets and discovered new prospecting clues.The most significant mineralization combination in this area is Au-Cu-Ag-Mo-Bi, followed by Pb-Zn; The V-Ti-Co-Mn combination and Ni-Cr combination can serve as exploration elements, indicating that there may be favorable mineralization mechanisms in the center and deep parts of the combination anomaly zone. Finding volcanic craters and hidden explosive breccia tubes in the distribution areas of volcanic rocks in this region or area is an important direction for mineral exploration; In the area of Shichang Fangzi Village in the eastern part of the research area, there is a comprehensive zoning with a F₂-F₄-F₁ three factor combination model. The Mesozoic Buliu sequence and Weideshan sequence rock bodies are favorable geological bodies for mineralization, and the NE trending structural belt is a favorable place for mineralization, indicating the direction of prospecting.