Abstract: China's complicated geological background and metallogenic environment have decided that the regional geochemical exploration can play an important role in the field of China's mineral resources prospecting. This is the strategic selection under special metallogenic conditions. The first round of regional geochemical exploration of China was carried out during mid-1950s. Since then, we carried out the second and third round of regional geochemical exploration. Until now, China's regional geochemical exploration has gone through a history of 70 years, and showed unique functions in fields of the exploration and development of nonferrous metals, precious metals as well as the rare minerals, rare earth and scattered minerals. According to incomplete statistics, during 36 years (1979~2015) of the second and third round of regional geochemical exploration, totally 182 different kinds of large to super-large scale deposits were discovered in China mainly by means of regional geochemical exploration. Of which, 61 deposits have nonferrous metals, 93 deposits have precious metals, 24 deposits have critical and scarce minerals, and 4 deposits have other kinds of minerals. On average, 5.06 large to super-large deposits were discovered each year, and one large to super-large deposit was discovered within every 37,000 square kilometers-Calculated on the basis that the second and third round of regional geochemical exploration covered 6.68 million square kilometers' area of China. Regional geochemical exploration has achieved outstanding results in the field of mineral prospecting, and made great contributions in terms of ensuring and promoting China's economic development. As our country's basic, public good and strategic geological work, regional geochemical exploration comes into the 21^st century marked by big data and earth system science. Based on high precision and good quality big data, guided by metallogenic geochemical theories, and supported by modern science and technology, the regional geochemical exploration will start a new period of development. In the future, we'll continue to carry out the high technical standard and high quality regional geochemical exploration, achieve our goal of complete covering the whole area of mainland China with regional geochemical exploration, and provide more strategic prospective areas for our country's mineral resources exploration. On the basis of high-precision big data, metallogenic theories and modern science and technology, we'll establish AI and IT application system, so as to push forward the exploration and utilization of deep minerals, buried deposits as well as the critical and scarce minerals which are difficult to identify, and achieve greater breakthroughs in the geological exploration of mineral resources. By using big data technics, China's regional geochemical exploration team will continuously solve the mineral resources exploration and evaluation problems, and in this process, our geochemical exploration system will be gradually integrated into our country's science and technology advancement.