Abstract: This study conducted a profile spectrum survey in the southern Anhui Province using a portable gamma-ray spectrometer. Based on the differences in types and quantities of natural radioactive elements present in geological bodies, this study compared the stack plots of the characteristic parameters of U, Th, and K with geologic-topographic maps to further delineate the occurrence locations of ore bodies. Additionally, this study investigated the applicability of gamma-ray spectra to the exploration of fluorite deposits and provided empirical suggestions for parameter surveys and anomaly determination. The experimental results indicate that gamma-ray energy spectroscopy applies the exploration of fluorite minerals. Notably, Th can be used as a primary indicator, exhibiting low-amplitude anomalies, which correspond well with ore bodies. Besides, this element is applicable to other surrounding rock conditions. The analysis and verification from the perspective of environmental protection revealed that the gamma-ray radiation dose rates induced by fluorite vein ore bodies are far lower than their background values and can be used as a preliminary basis for ore prospecting.