Abstract: In recent years, the Yifeng-Fengxin area of Jiangxi Province has witnessed significant breakthroughs in the exploration of granite-hosted lithium deposits, making it one of China's significant lithium ore clusters. However, there have been few reports on the application and achievements of lithium-related techniques. Focusing on 2,343 stream sediment samples from a 1∶50,000 geochemical survey in the Yifeng-Fengxin area, this study statistically analyzed geochemical parameters of over 20 elements. Subsequently, beryllium (Be), lithium (Li), niobium (Nb), rubidium (Rb), and tin (Sn) were determined as elements related to the mineralization and association of lithium deposit. Among these, Li and Sn showed strong enrichment and significant differentiation. Using statistical methods such as cluster and factor analyses, the five elements were further grouped into three assemblages: Rb-Be, Li-Sn, and Nb. Besides, this study processed and analyzed the stream sediment data from the Yifeng-Fengxin area using the iterative method, determining the lower threshold of both geochemical anomalies. Then, single-element and multi-element geochemical anomalies were investigated, with lithium identified as the primary ore-forming element. These anomalies, featuring prominence and large scale, were primarily situated in the northern and northeastern parts of the survey area, with concentration centers located in muscovite granite outcrops. The Li-Sn assemblage, serving as an indicator for granite-hosted lithium deposits, coincides well with the distribution of ore bodies. This confirms that Li-Sn assemblage anomalies in stream sediments can effectively delineate granite-hosted lithium deposits. Based on the anomaly characteristics from the 1∶50,000 stream sediment survey, two prospect areas were delineated in the periphery, providing guidance for further lithium exploration.