Abstract: The Weihe Basin boasts abundant helium resources.Vigorously exploiting these resources is significant for national development and social progress.However,the complex geographical and geological conditions in the basin pose great challenges in seismic image processing and interpretation,severely hindering the identification of helium-rich natural gas traps and reservoir prediction.This study delved into the difficulties and challenges in processing the seismic data from the Huazhou-Huayin area.Based on the seismic exploration objectives,an effective seismic data processing workflow was developed,along with targeted technical solutions,to address the difficulties in seismic data processing.The results of this study demonstrate that the quality of seismic data processing can be effectively improved using techniques,such as pseudo-3D tomographic static correction,global optimization residual static correction,multi-domain and multi-method serial denoising,multiple amplitude compensation and wavelet correction,and prestack time migration.These improvements provide critical technical support for the exploration and production of helium-rich natural gas in the exploration area,and valuable insights for seismic data processing for other regions within the basin.