Abstract: Since individual geophysical exploration methods suffer the multiplicity of solutions, comprehensive geophysical prospecting has been extensively applied in deep ore prospecting presently. This study conducted the geological exploration of the Duhu porphyry copper deposit in Xinxing County using multiple geophysical methods such as high-precision magnetic survey and controlled source audio-frequency magnetotellurics (CSAMT). It was inferred that the CSAMT-derived medium-low resistivity anomalies and the low-gentle anomalies derived from the high-precision magnetic survey serve as significant prospecting indicators. Satisfactory results were achieved in follow-up verification of the anomalies. Specifically, copper, molybdenum, silver, and gold mineralized bodies with a cumulative thickness of 178.2 m were identified in a 1 000 m deep borehole, with the highest copper grade of 1.45%. The application of comprehensive geophysical prospecting holds great significance in guiding the exploration of porphyry copper deposits in western Guangdong.