Abstract: The tin-polymetallic mining area of the Yue'e ore district, XiengKhouang Province, Laos, is located in the west of the XiengKhouang Laos-Changshan Vietnam tectonic magmatic belt. Based on the 1:25 000 valley system soil geochemical survey, combined with an analysis of the characteristics of element variation coefficients and concentration coefficients, the correlation of elements, anomaly verification, and gold and other polymetallic ore prospecting potentials, the authors optimized multiple target and prospects areas. The position of the mineralized body was inferred based on geochemical exploration anomalies in key target areas. Through trench verification and drilling engineering verification, good prospecting results were achieved. The area is considered to have copper, tin, lead, zinc, tungsten. It is shown that this method can quickly delineate the prospecting target area and distant scenic area in the thick coverage area and extensive blank research area of Southeast Asian tropical monsoon climate, and can provide an effective basis for the next exploration work.