To achieve the goals of peak carbon dioxide emissions and carbon neutrality, geothermal energy has great prospects for utilization as a type of widely distributed green and clean energy. The tectonic fissure-hosted geothermal water is regarded as an important type of hydrothermal energy for development and utilization because of its high water yield and easy reinjection. This study systematically analyzed the regional structures, formation lithology, water storage space, and water yield property of the urban area of Meixian County in the west of Guanzhong Plain through the regional integrated geophysical exploration, aiming to guide the target area prediction and well placement of geothermal wells. The results show that three concealed faults are present in the target area, of which two faults with favorable water yield property and large scale can be regarded as the faults of the target area. Based on this, geothermal wells were arranged near the fault prediction lines on the hanging wall of the faults, and the weathered zones of the bedrock surfaces were penetrated vertically along the dip angles of the faults. Given the actual geological conditions, such as the faults and the burial depth of the bedrock surface, the geothermal wells had an average drilling depth of 500 m from the bedrock surface. The drilling results show that there are dual-structure thermal reservoirs in the target area, including thermal reservoirs of pore water in the Neogene clastics and those of the bedrock fissure water. Among the eight geothermal wells, seven wells have a water yield of more than 100 m?/h, which mainly originates from the bedrock fissure water, and only one well has a relatively low water yield, which is mainly sourced from the pore water in the Neogene clastics.