In this paper, with the metallogenic series theory as the guide and the geochemical data as the basis, all lead-zinc ore deposits in the region were classified into two sub-series, i.e., LF type (with low content of iron group elements) and HF type (with high content of iron group elements), and a regional geochemical prognostic model was set up by using the logical information method. The model holds that the metallogenic environment of the LF type is structural reductive space whereas that of the HF type reflects entirely characteristics of sedimentary minerallization, with no evidence of tectonic minerallization. A comparison of the prospecting model of the HF type with the prediction model of the VMS type reveals that their thermal dynamic mechanisms are different: the former is related to basic-ultrabasic rock intrusion, while the latter to acidic rock intrusion.