Using such isotopic means as hydrocarbon acidolysis, top air measurement, adsorption filament and carbon methane, the authors made integrated oil and gas geochemical exploration and established goechemical anomaly models for indices of these methods in this area. On the basis of summing up anomaly regularity of known oil and gas areas, the geochemical methods and index combinations were optimized and then applied to unknown areas, which led to the delineation of oil and gas target areas. The relationship between surface geochemical anomalies and characteristics of petroleum geology is also discussed, which is helpful to geological interpretation of geochemical anomalies.