A certain mining area is located in the middle of Wumeng Mountain area in northwestern Guizhou Province, which belongs to a contiguous special poverty-stricken area. In combination with the lead-zinc metallogenic background as well as the orebody characteristics in different depths (100~800 m), the authors chose the combination of such geophysical techniques as IP ladder sweeping, IP three pole sounding and audio-frequency magnetotellurics (utilizing two detecting devices for different depths, EH-4 and V8), deduced geophysical anomalies and guided the deployment of 10 drill holes, which all intersected industrial orebodies, thus expanding the lead-zinc reserves in the mining area. According to the application effect of the comprehensive geophysical prospecting method, the authors put forward some comprehensive geophysical prospecting methods which can tackle corresponding types of lead-zinc deposits in this area, thus providing guidance for further geological prospecting breakthrough.