Located geotectonically within the North Himalayan epicontinental warped fault belt in the middle segment of the Tethyan-Himalayan tectonic domain, the Zhaxikang lead-zinc polymetallic deposit in Tibet is one of the rarely-seen large-size lead-zinc-silver association deposits with rich sulfosalt minerals in Tibet. The ore deposit is mainly hosted in Lower Jurassic Ridang Formation, with the ore-hosting rocks being carbon-bearing calcareous slate,calcareous slate,sericite slate,shale and quartz sandstone. The orebodies are strictly controlled by two sets of NE-SW trending faults and exhibit veinlike and lenticular forms. In view of characteristics of the ore-controlling structures, the authors employed the high density resistivity method, induced polarization method, transient electromagnetic method and audio frequency magnetotelluric method to conduct investigation in the typical ore deposit and its periphery, and made inverse comparison of the effects of some methods. In combination with the previous geological and geophysical data as well as engineering verification, the authors hold that the magnetotelluric method and the induced polarization method are fairly credible and economical. In addition, different inversion methods should be jointly arranged to analyze and judge the typical deposits; only in this way can the aim of preliminary prognosis of the orebody be achieved.